Building synergistic nanoplatforms via dendrimer-small organic molecule handshakes: Heterocycle ligation as a promising strategy. Chithra R. Nair and K G Sreejalekshmi. Materials Today Chemistry, 38, 102099  (2024)

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PAMAM-guanylthiourea conjugates mask furin’s substrate binding site: Mechanistic insights from molecular docking and molecular dynamics studies assist the design of potential furin inhibitors. Chithra R. Nair and K G Sreejalekshmi New J. Chem., 47, 12468-1 (2023)

 

Discovery of full color emissive thiazole fluorophores in solution and solid states: The core is central and regulating torsional barrier does the trick! R Radhakrishnan, BB Sinu, V Anilkumar, KG Sreejalekshmi. Dyes and Pigments 181, 108560 (2020)

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Computational Design, Synthesis and Structure Property Evaluation of 1, 3-Thiazole Based Colour Tunable Multiheterocyclic Small Organic Fluorophores as Multifunctional Molecular Materials.

R Radhakrishnan, KG Sreejalekshmi - The Journal of Organic Chemistry, DOI: 10.1021/acs.joc.7b02978 (2018)

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Enriching biologically relevant chemical space around 2-aminothiazole template for anticancer drug development

S Titus, KG Sreejalekshmi Medicinal Chemistry Research,  27 (1), 23-36 (2017)

 

Fluorophores based on a minimal thienylthiazole core: towards multifunctional materials with solid state red emissions, solvatochromism and AIE behaviour

R Radhakrishnan, KG Sreejalekshmi RSC Advances 6 (39), 32705-32709 (2016)

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One-pot four-component synthesis of 4-hydrazinothiazoles: novel scaffolds for drug discovery

S Titus, KG Sreejalekshmi Tetrahedron Letters 55 (40), 5465-5467 (2014)

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One-pot sequential multicomponent route to 2, 4-diaminothiazoles—a facile approach to bioactive agents for cancer therapeutics

KG Sreejalekshmi, KN Rajasekharan Tetrahedron Letters 53 (28), 3627-3629 (2012)

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A Facile, Sequential Multicomponent Approach to N-Aminoamidinothioureas—Versatile Synthons to Bioactive Heterocycles

KG Sreejalekshmi Phosphorus, Sulfur, and Silicon 185 (9), 1830-1837 (2010)

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Synthesis and cytotoxicity studies of thiazole analogs of the anticancer marine alkaloid dendrodoine

TF Reji, SKC Devi, KK Thomas, KG Sreejalekshmi, SL Manju, M Francis, SK Philip, A Bharathan, KN Rajasekharan Indian Journal of Chemistry -B, 47B, (07) (2008)

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An efficient protocol for solid phase aminothiazole synthesis

KG Sreejalekshmi, SKC Devi, KN Rajasekharan Tetrahedron letters 47 (35), 6179-6182 (2006)

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4‐Amino‐5‐benzoyl‐2‐(4‐methoxyphenylamino) thiazole (DAT1): a cytotoxic agent towards cancer cells and a probe for tubulin‐microtubule system

S Sengupta, SL Smitha, NE Thomas, TR Santhoshkumar, SKC Devi,  Kumaran G Sreejalekshmi, Kallikat N Rajasekharan

British journal of pharmacology 145 (8), 1076-1083 (2005)

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Conference Papers/posters

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• Chithra R. Nair, K.G.Sreejalekshmi, PAMAM-Schiff Base Conjugates as Potential Theranostics,  Annual Technical Meeting of MRSI Trivandrum Chapter, May 2023, Materials Research Society of India.

• Chithra R. Nair, K G Sreejalekshmi. Design and development of Poly(amidoamine) Dendrimer-Heterocycle conjugates as nanotheranostics at the Polymer Processing Society Asia-Australasia Regional Conference (PPS – 2023), November 29, 2023 to December 02, 2023 in Kovalam, Kerala, India (BEST POSTER AWARD)

• Chithra R. Nair, K.G. Sreejalekshmi PAMAM-Guanylthiourea platform for the synthesis of PAMAM-heterocycle conjugates; ACS- India Satellite Event Virtual Science Communication Competition, Hybrid mode event, March 21, 2022

• Chithra R. Nair, K.G. Sreejalekshmi Guanylthiourea-tethered PAMAM: A simple and versatile platform for the synthesis of PAMAM-heterocycle conjugates; ACS Spring 2022, Hybrid mode event, San Diego CA, March 20-24, 2022

• Chithra    R. Nair, K. G. Sreejalekshmi; Virtual Screening of 1,3-Thiazole Containing Small Molecule Drugs Against SARS-CoV-2. (poster presentation) National Conference on Recent Trends in Materials Science and Technology (NCMST-2019) organized by Department of Chemistry, IIST, Thiruvananthapuram, 07-09 December, 2020.

• Chithra R Nair, Sarah Titus and KG Sreejalekshmi; Molecular Design for Dendrimer based Nanotheranostics: Conjugation of heterocycles as a viable strategy International Conference NANOBIOTEK at Aerocity Delhi during 20-22 November 2019.

• Aditya Gohad, Athira S. Vijayan, Chithra R. Nair, KG Sreejalekshmi; Nonionic surfactants with solid and solution state emissions: Synthesis, characterisation and photophysical property evaluations; National Conference on Recent Trends in Materials Science and Technology (NCMST 2019) during 18-20 December 2019.

• Jasmine P. Jacob, Muskan Bhatnagar, Chithra R. Nair, KG Sreejalekshmi; Adamantyl thiazoles as a versatile building block for diamondoid nanostructures: Synthesis, characterisation and property evaluations; National Conference on Recent Trends in Materials Science and Technology (NCMST 2019) during 18-20 December 2019. 

• Dona Mariya Vincent, Rakesh R., Sarah Titus, K. G. Sreejalekshmi. “Colorimetric sensors based on Novel 2-amino- 4-hydrazinothiazoles for anion detection”. National Conference on Recent Trends in Material Science & Technology (NCMST- 2016), July 12-14, 2016, Indian Institute of Space Science and Technology, Thiruvananthapuram, Kerala, India

• Noufal M.C., Sarah Titus, Dona Maria Vincent, Rakesh R., K.G. Sreejalekshmi. “Azaindole fragment decoration on 4-hydrazinothiazole scaffold as a useful strategy for designing aurora kinase inhibitors: Insights from virtual screening of a synthetically feasible combinatorial library” International Conference on Drug Design, April 7-9, 2017, JNU-New Delhi, India. (BEST POSTER AWARD)

• S.Titus and K.G. Sreejalekshmi, Coumarinoyl-1,3-thiazole conjugated PAMAM dendrimers as highly emissive  solvatochromic fluorescent nanoprobes. Polymer Conference for Young Researchers (PCYR-2015), 18th December 2015, NIIST, Thiruvananthapuram.

• R. Rakesh and K.G. Sreejalekshmi, Exceptional large Stokes shift fluorophores: Design, synthesis and rationalization of photophysical properties of novel heterocyclic dyes, 17th CRSI National Symposium in Chemistry, 06-08 February, 2015, CSIR-NCL, Pune.

• S. Titus and K.G. Sreejalekshmi, Design and synthesis of coumarinoyl-1,3-thiazole conjugated PAMAM as multifunctional fluorescent dendritic nanoprobes, 17th CRSI National Symposium in Chemistry, 06-08 February, 2015, CSIR-NCL, Pune.

• R. Rakesh and K.G. Sreejalekshmi, Synthesis, crystal structure and electronic properties of a thienylthiazole hybrid- A combined theoretical and experimental approach, 8th Asian Photochemistry conference (APC-2014), 10-13th November, Rajiv Gandhi Convention Centre, Kovalam, Thiruvananthapuram.

• S. Titus and K.G. Sreejalekshmi, “Synthesis and solvatochromism of coumarin conjugated PAMAM: in search for a novel imaging probe, National Event on Research Scholar’s Day, held at IIST Thiruvananthapuram, India, December 2013.

• S. Titus and K.G. Sreejalekshmi,  “Computational approach towards the development of densely functionalized thiazoles as novel anticancer agents” 4th International conference on stem cells and cancer, Haffkines Institute, Mumbai, India, 19-22nd October , 2013. (BEST POSTER AWARD)

• S. Titus and K.G. Sreejalekshmi, ‘Recent Advances in Computational Drug Design’ (RACDD-2013) held at IISc Bangalore during September 16-17th, 2013 (BEST POSTER AWARD).

• A.S. Rama Teja, Sarah Titus, R. Rakesh, K.G. Sreejalekshmi; “Hymecromone functionalized poly(4-vinylpyridine) and its photodeformation” National Seminar on Recent Trends in Materials Science and Technology, held at department of Chemistry, Indian Institute of Space Science  and Technology, Thiruvananthapuram, India 10-12th July 2013.

• Sarah Titus and K.G. Sreejalekshmi; “Molecular Docking studies on densely functionalized hydrazinothiazoles” National event Research Scholar’s Day 2012, held at Indian Institute of Space Science  and Technology, Thiruvananthapuram, India 19-21st December 2012.

• K.G. Sreejalekshmi, M. Francis and K.N. Rajasekharan; “Polymer supported synthon for combinatorial heterocycle synthesis” International Conference on ‘Polymers for Advanced Technologies’, held at RRL (CSIR), Thiruvananthapuram, India, 14th December 2004.

• K.G. Sreejalekshmi, T.F.A.F. Reji, S.K.C. Devi and K. N. Rajasekharan; “Isolation and combinatorial analog synthesis of anticancer marine alkaloids”, “International Conference on “Natural Products, Free Radicals and Radioprotectors in Health” held at Department of Biochemistry, Annamalai University, Annamalainagar, India, 17-19 January 2004.

• K.G. Sreejalekshmi, S. Anusya, V.P. Menon, S. Sengupta and K.N. Rajasekharan; “Versatile approach to bioactive 2,4-diaminothiazoles  by novel solid phase heterocyclic synthesis”, “Fifth National Symposium in Chemistry”, held at CLRI (CSIR), Chennai, India, 7-9 February 2003.

• S.K.C. Devi, T.F.A.F. Reji, K.G. Sreejalekshmi and K. N. Rajasekharan; “Anticancer marine alkaloids”, National Conference on “Natural Products in Health” held at Department of Biochemistry, Annamalai University, Annamalainagar, India, 26-27 February 2005.

• S. Sengupta, S.L. Smitha, N.E. Thomas, T.R. Santosh, S.K.C. Devi, K.G. Sreejalekshmi, and K.N. Rajasekharan;  DAT1: “An antimitotic and cytotoxic agent towards cancer cells and a probe for tubulin-microtubule system”, “Proceedings of the International Conference on Biotechnology and Neuroscience”, Cochin, India, 2004.

• T. F. A. F. Reji, S.K.Chithralekhadevi, S.L. Manju, K.G. Sreejalekshmi and K. N. Rajasekharan; “New indoloyl-2,4-diaminothiazoles as dendrodoine analogs – synthesis and cytotoxicity”, “Fifth National Symposium in Chemistry”, held at CLRI (CSIR), Chennai, India, 7-9 February 2003.

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Multiheterocyclic systems

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Expanding the donor–acceptor toolbox with a minimal 5-(thiophen-2-yl)-1, 3-thiazole core: transition metal-free synthesis and molecular design for HOMO–LUMO energy modulations

R Radhakrishnan, KG Sreejalekshmi New Journal of Chemistry 40 (4), 3036-3039 (2016)

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Propeller-shaped molecules with a thiazole hub: structural landscape and hydrazone cap mediated tunable host behavior in 4-hydrazino-1, 3-thiazoles

S Titus, KG Sreejalekshmi CrystEngComm 17 (31), 5978-5986 (2015)

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Conference Papers/posters

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• Rakesh R., K.G. Sreejalekshmi. “Exploring 1,3-thiazole scaffolds for structure property relationships and dendritic architecture”. 18th Tetrahedron Symposium, June 27-30, 2017, Budapest, Hungary. (accepted for presentation)

• Rakesh R., K. G. Sreejalekshmi. “Thienylthiazole: a promising core for theranostics” National Seminar on Current Trends in Chemistry (CTriC 2017), February 3-4, 2017, Cochin University of Science and Technology, Kochi, Kerala, India.

• Rakesh R., K. G. Sreejalekshmi. “Diversity-oriented design and synthesis of multi-heterocyclic donor acceptor hybrid cores based on 1, 3-thiazole”. 21st  International Conference on Organic Synthesis (ICOS 21), December 11-16, 2016, IIT Mumbai, India.

• S. Titus and K.G. Sreejalekshmi, Supramolecular assemblages in multicomponent molecular crystals of 4-hydrazinothiazoles, RSC Roadshow India, 10th November, 2014, IIT-Madras.

• S. Titus and K.G. Sreejalekshmi, Synthesis and single crystal X-ray studies on aminothiazole monohydrate, a structural analogue to dasatinib, International Conference on Materials and Characterization Techniques (ICMCT-2014), 10- 12th March, 2014, VIT university, Vellore.

• R. Rakesh, S. Titus and K.G. Sreejalekshmi, “Electronic structures and spectroscopic properties of benzopyranone derivatives : A DFT study, National Event on Research Scholar’s Day, held at IIST Thiruvananthapuram, India, December 2013.

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Smart Materials & Space Systems

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Chetia, T., Rajaram, D. and K.G. Sreejalekshmi. Aerodynamic and flight dynamic parametric studies of a flapping wing, International Journal of Intelligent Unmanned Systems (2022), Vol. ahead-of-print No. ahead-of-print. https://doi.org/10.1108/IJIUS-06-2021-0039

 

Sathasivam M, Hosamani R, K Swamy B, K G Sreejalekshmi. Plant responses to real and simulated microgravity. Life Sciences in Space Research. 74-86, (2021):DOI: 10.1016/j.lssr.2020.10.001.

 

Chellapurath M, Noble S, K G Sreejalekshmi. Design and kinematic analysis of flapping wing mechanism for common swift inspired micro aerial vehicle. Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science. (2020) doi:10.1177/0954406220974046

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Theoretical predictions on microphase separation in polyurethane: Combinatorial design, synthesis and demonstration of shape memory property

E Swathi and KG Sreejalekshmi, Materials Today Communications, 16, 71-80 (2018) https://doi.org/10.1016/j.mtcomm.2018.04.007 

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Biomimeticity in tissue engineering scaffolds through synthetic peptide modifications—Altering chemistry for enhanced biological response

KG Sreejalekshmi, PD Nair Journal of biomedical materials research Part A 96 (2), 477-491 (2011)

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Conference Papers/posters

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• K. G. Sreejalekshmi and Srujana Juratagi. Table-top RPM for optimizing space biology experiments: Design, fabrication, and validation through seed germination experiments, 22nd  National Space Science Symposium (NSSS 2024), GOA University, 26th February – 01st March 2024

• Bilga Bhuvan and K G Sreejalekshmi, Alginate Hydrogel loaded with Hemigraphis colorata Extract as Bionk for 3D Printing of Wound Healing Patches, Polymer Processing Society-Asia- Australasia Regional Conference (PPS 2023),  29th November- 2nd December, 2023 in Kovalam, Kerala, India

• Shruthi Diwase, K G Sreejalekshmi. Investigations on Silica Aerogel as CO2 adsorbents International Conference on Materials Science and Nanotechnology for sustainable applications, organised by Department of Basic and Applied Sciences, MGM UNiversity, Aurangabad, India during 23-24 March 2023 (BEST POSTER AWARD)

• Adarsh Jayagopal, K G Sreejalekshmi Optimizing the Sabatier reactor design for power-to-gas applications: A computational approach.Indo-German International Conference of "Metrology for the Deployment of Green Hydrogen and Renewable Fuels in India"; Virtual event, April 4-6, 2022  (BEST POSTER AWARD)

• Akhil Madhavan K, K G Sreejalekshmi. Development of Hardware for Biology in Spaceflight: Exploring the Prospects of Design for Additive Manufacturing (DfAM) 8th International Conference (online) on Product Life Cycle Modeling, Simulation and Synthesis (PLMSS-2021) Dec 17-18 December, 2021

• Tandralee Chetia, Dhayalan and KG Sreejalekshmi; Aerodynamic and Flight Dynamic Design of a Flapping Wing MAV; 3rd National Conference on Academic, Industrial, Scientific and Defence Research in Mechanical and Aeronautical Engineering Research organized by Society of Aeronautical Engineers on June 01st 2019 at Government Museum,  Chandigarh

• C Mrudul, Sam Noble and K G Sreejalekshmi. "Design of Flapping Wing Mechanism for Bionic Micro Aerial Vehicle", Fourth International Conference on Materials Mechanics and Management from 13th -15th July 2017, CET, Trivandrum, Kerala

• E. Swathi, R. Rakesh, S.Titus, K.G. Sreejalekshmi. “A combined theoretical and experimental investigation on the effect of microphase separation on shape memory behaviour of polyurethane” Macro-2017- International Conference on Polymer Science and Technology, January 8-11, 2017, Thiruvananthapuram, Kerala, India 2017.

• Dona Mariya Vincent, Rakesh R., Sarah Titus, K. G. Sreejalekshmi. “Colorimetric sensors based on Novel 2-amino- 4-hydrazinothiazoles for anion detection”. National Conference on Recent Trends in Material Science & Technology (NCMST- 2016), July 12-14, 2016, Indian Institute of Space Science and Technology, Thiruvananthapuram, Kerala, India.

• E. Swathi, K.G. Sreejalekshmi. “Effect of microphase separation on shape memory properties of polyurethane”, National Conference on Recent Trends in Materials Science &  Technology (NCMST-2016), July 12-14, 2016, Indian Institute of Space Science and Technology, Thiruvananthapuram, Kerala, India.

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Environmental Science &Engineering

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Removal of Cu(II) from aqueous phase using tailor made sulphur impregnated activated carbon inspired by Claus Process.

K. A. Krishnan, K.G. Sreejalekshmi, Vinu V. Dev, Sibin Antony, H. Mahadevan

Desalination and Water Treatment, 80, 214–222, (2017)

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Evaluation of adsorption properties of sulphurised activated carbon for the effective and economically viable removal of Zn (II) from aqueous solutions

KA Krishnan, KG Sreejalekshmi, V Vimexen, VV Dev

Ecotoxicology and environmental safety 124, 418-425 (2016)

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Adsorptive removal of 2, 4-dinitrophenol using active carbon: kinetic and equilibrium modeling at solid–liquid interface

K Anoop Krishnan, S Sini Suresh, S Arya, KG Sreejalekshmi

Desalination and Water Treatment 54 (7), 1850-1861 (2015)

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